Edema and Related Medical Conditions

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Friday, January 11, 2013

Massive corneal edema treated with corneal cross-linking.

Massive corneal edema treated with corneal cross-linking.



Ophthalmic Complex Operating Unit, IRCCS-Hospital Casa Sollievo Della Sofferenza, San Giovanni Rotondo (Foggia), Italy. antoniolaborante@virgilio.it



Massive corneal edema disrupts the fine architecture of corneal stroma that guarantees its transparency, causing opacities that seriously impair clear vision and are usually solved by corneal transplant. Corneal cross-linking, a treatment developed to halt keratoconus progression, results in a loss of water and a compaction of corneal stroma. It might therefore be useful to improve the pathologic edematous condition of some corneas, ameliorating visual acuity and allowing more time for a surgical procedure of keratoplasty.


Six patients with visual impairing corneal edemas further to lens phacoemulsification, penetrating keratoplasty, or post-infective neovascularization were treated with corneal cross-linking alone, or in combination with amniotic membrane apposition with or without anti-angiogenic therapy.


 All patients partly resolved the edematous condition, improving both corneal transparency and visual acuity.


 Corneal cross-linking appears to be a useful method to treat massive corneal edemas, so that keratoplasty can be at least delayed, and need not to be an emergency treatment in these cases.

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