Comparison of obstructive sleep apnea patients with and without leg edema
Sleep Med. 2008 Feb 11
Iftikhar I, Ahmed M, Tarr S, Zyzanski SJ, Blankfield RP.
Department of Internal Medicine, Fairview Hospital, Cleveland Clinic System, Cleveland, OH, United States.
BACKGROUND: To determine the proportion of patients with obstructive sleep apnea (OSA) who have leg edema, and to identify differences between edematous and non-edematous OSA patients.
METHODS: Retrospective, cross-sectional study of 378 patients with OSA (apnea/hypopnea index [AHI] 15) who had neither heart failure nor chronic lung disease.
RESULTS: Thirty-five percent (133/378) of the subjects with OSA had bilateral leg edema. Eighty-one percent (108/133) of the edematous subjects had mild pitting that was 1+. Compared to the non-edematous OSA subjects, the edematous subjects were older (age=51+/-13 versus 45+/-13 years, p=0.001), more obese (body mass index=39+/-9 versus 33+/-8kg/m(2), p=0.001), had more severe OSA (AHI=46+/-71 versus 27+/-29, p=0.004), spent a greater proportion of sleep time with an oxygen saturation <90% p="0.001)," p="0.001)" p="0.001)." p="0.04).
CONCLUSIONS: Approximately one-third of OSA patients have edema. Edematous OSA patients are older, more obese, more likely to have diabetes mellitus and hypertension, and have more severe OSA than OSA patients who lack edema.