Edema and Related Medical Conditions

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Friday, March 31, 2006

Infantile acute hemorrhagic edema

Infantile acute hemorrhagic edema and rotavirus infection.

Operative Unit of Dermatology, 1st Medical Department, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.


Infantile acute hemorrhagic edema (AHE) is a benign condition characterized by a dramatic onset of inflammatory edema and ecchymotic purpura in a target or cockade pattern. It is considered an uncommon form of cutaneous vasculitis occurring in children younger than 2 years of age. The outbreak is frequently preceded by an immunization or various infections. We describe an 11-month-old girl with rosette-shaped purpuric plaques on the face and limbs, clinically consistent with a diagnosis of AHE of the skin, associated with fever and diarrhea. Laboratory investigations showed a rotavirus infection, which has not previously been reported in association with AHE of the skin. The disease had a benign course without relapses. Appropriate microbiologic investigations are advisable to confirm the possible etiologic role of rotavirus.

Publication Types:
Case Reports

PMID: 15461759 [PubMed - indexed for MEDLINE]

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Report of eight infants with acute infantile hemorrhagic edema and review of the literature

Caksen H, Odabas D, Kosem M, Arslan S, Oner AF, Atas B, Akcay G, Ceylan N.

Department of Pediatrics, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.

Acute infantile hemorrhagic edema (AIHE) is a cutaneous leukocytoclastic vasculitis, clinically characterized by the symptom triad of fever, large purpuric skin lesions, and edema. The clinical picture has a violent onset, a short benign course, and spontaneous complete recovery. In this article, we present eight patients who were admitted with rashes on the skin and edema on the eyelids and extremities, and were diagnosed with AIHE according to their clinical and histopathological features (immunohistological study was also performed in three of them). Our purpose was to emphasize that, aside from Henoch-Schonlein purpura, meningococcemia, septicemia, and purpura fulminans, AIHE benign disorder should also be considered in the differential diagnosis to determine the clinical course and treatment protocol in patients with purpuric rashes.

Publication Types:
Case Reports

PMID: 12081160

[PubMed - indexed for MEDLINE]

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Infantile acute hemorrhagic edema of the skin.

Paradisi M, Annessi G, Corrado A.

Istituto Dermopatico dell'Immacolata, Rome, Italy.

Infantile acute hemorrhagic edema (AHE) of the skin is an uncommon form of cutaneous leukocytoclastic vasculitis that occurs in children younger than 3 years. We describe a 10-month-old boy with AHE, in whom the disease appeared after antibiotic treatment for an acute respiratory illness. AHE presented with fever, acral edema, and rosette-shaped purpuric plaques on the face and limbs. The causes of AHE are unclear, as is its nosologic position. Some authors consider the disease as a purely cutaneous form of Henoch-Schonlein purpura, and others believe that AHE should be regarded as a distinct clinicobiologic entity within the spectrum of leukocytoclastic vasculitis.

Publication Types:
Case Reports

PMID: 11534914 [PubMed - indexed for MEDLINE]

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Infantile Acute Hemorrhagic Edema Diagnostic Images

Acute Hemorrhagic Edema of Infancy - eMedicine

Acute Hemorrhagic Edema of Infancy - Isreal Medical Assoc. Journal

Urticarial vasculitis of infancy (Acute hemorrhagic edema)